Shopping at thrift stores has become more commonplace in recent years and you can really find some great things if you take your time and take a good look around the stores with both eyes open.
I have found many great things at thrift stores including vintage rock records from bands such as The Beatles and Jimi Hendrix, vintage Levi's 501 jeans circa World War 2 and designer suits.
The key to finding great things is doing your homework and knowing the bad from the good. You also can't expect to find a great find on every trip to the thrift shop. The key to finding unique, vintage items is patience and regular visits.
The more often you check back into your local thrift store, the better the odds of finding a unique, valuable item. It really is a numbers game when exploring thrift stores.